Nursing Pathophysiology

Draft Study Notes: Pathophysiology of Bacterial Vaginosis

Pathophysiology of Diagnosis (3 of or gram stain)

1. White vaginal discharge coating the vaginal wall, and its pathophysiology of bacterial vaginosis
2. A ph of above 4.5
3. Whiff test/ fishy odor
4. Clue cells- coccoid bacteria

Treatment

• Symptomatic- treat
• Asymptomatic- only pg women preparing for termination

First choice: Metronidazole oral 500 mg, metronidazole gel, > similar effectiveness

• alcohol (avoid during and one day after completion) use may lead to disulfiram-like reactions
• clindamycin cream> less effective than met, oil-based hence weaken latex condoms and diaphragms,
• probiotics- controversial with no reliable evidence
• treatment of both partners- no evidence to support use hence not recommeneded

Pregnant women: associated with premature rapture of membranes, preterm labor, and postpartum endometriosis >screen when pg dgx is made. Use oral metronidazole recommended as opposed to topical

• Relapse and reinfection: (3 episodes with 12 months)
• Suppressive therapy- met gel (0.75%) for 4-6 months
• Vaginal boric acid 600 mg for 21 days + metronidazole for seven days